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NABP Exam NAPLEX Topic 10 Question 18 Discussion
Actual exam question for
NABP's
NAPLEX exam
Question #: 18
Topic #: 10
[All NAPLEX Questions]
Topic #: 10
Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?
Suggested Answer:
C
Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).
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