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NABP Exam NAPLEX Topic 5 Question 50 Discussion
Actual exam question for
NABP's
NAPLEX exam
Question #: 50
Topic #: 5
[All NAPLEX Questions]
Topic #: 5
Which of these medicines is well-known to cause a positive direct Coombs test?
Suggested Answer:
A
The direct Coombs test is used to test for autoimmune hemolyticanemia -- a condition in which the body attacks red blood cells, leading to anemia. Some drugs can cause a positive direct Coombs test -- methyldopa being one of the most well-known (via IgG-mediated type II hypersensitivity reaction). Other drugs that can cause this effect include quinidine (IgM-mediated activation) and penicillins (at very high doses).
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