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NABP Exam NAPLEX Topic 5 Question 97 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 97
Topic #: 5

[All NAPLEX Questions]

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

ACYP3A4

BCYP2C9

CCYP2C19

DCYP2D9

ECYP1A2

Show Suggested Answer

Suggested Answer: C

Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).

by Shelton at Nov 18, 2024, 03:59 AM

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Val

11 days ago

But omeprazole inhibits CYP2C19, which is involved in warfarin metabolism.

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Pearlene

17 days ago

C'mon, it's gotta be C) CYP2C19. Everyone knows that's the one responsible for warfarin metabolism, and omeprazole messes with that.

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Yvette

2 days ago

I think you're right, it's C) CYP2C19.

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Donette

18 days ago

I disagree, I believe the correct answer is B) CYP2C9.

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Val

24 days ago

I think the answer is C) CYP2C19.

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Angelyn

24 days ago

Hmm, I think the answer is B) CYP2C9. Omeprazole is known to inhibit this enzyme, which is also involved in the metabolism of warfarin.

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Dick

9 days ago

It's important to monitor patients closely when using both medications together.

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Solange

14 days ago

That's correct, the interaction can lead to increased INR and PT.

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Valda

15 days ago

I agree, omeprazole inhibits CYP2C9 which is involved in warfarin metabolism.

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